Delta-G-VSV Pseudotyping System
The glycoprotein (G protein) of VSV is responsible for the attachment and entry of VSV into a susceptible host cell and is therefore essential for virus infectivity. To identify and dissect the signals required for the replication and assembly of VSV Dr. Michael Whitt has developed a "reverse genetics" system in which the G protein of VSV has been deleted ( rVSV-ΔG). rVSV-ΔG has been used to produce VSV pseudotypes containing the envelope glycoproteins of heterologous viruses including viruses that require high-level containment. Since the infectivity of rVSV-ΔG is restricted to a single round of replication, analyses of viral entry can be performed using just biosafety level 2 (BSL-2) containment.
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