Delta-G-VSV Pseudotyping System

The glycoprotein (G protein) of VSV is responsible for the attachment and entry of VSV into a susceptible host cell and is therefore essential for virus infectivity. To identify and dissect the signals required for the replication and assembly of VSV Dr. Michael Whitt has developed a "reverse genetics" system in which the G protein of VSV has been deleted ( rVSV-ΔG). rVSV-ΔG has been used to produce VSV pseudotypes containing the envelope glycoproteins of heterologous viruses including viruses that require high-level containment. Since the infectivity of rVSV-ΔG is restricted to a single round of replication, analyses of viral entry can be performed using just biosafety level 2 (BSL-2) containment.

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Cell Line 
(1)
Plasmid 
(24)
Virus 
(8)
Gene/insert name
ΔG- DsRed 
(2)
ΔG-GFP 
(2)
ΔG-Luciferase 
(2)
ΔG-N/P-MCS2-2.6 
(2)
ΔG-P/M-MCS2-2.6 
(2)
ΔG-PL 2.5 
(2)
rVSV-ΔG-GFP-2.6 
(2)
VSV large polymerase subunit (L) 
(1)
VSV nucleocapsid (N) protein 
(1)
VSV nucleocapsid (N) protein; VSV phosphoprotein (P); VSV large polymerase subunit (L); VSV-Indiana glycoprotein (G) 
(1)
VSV phosphoprotein (P) 
(1)
VSV-ΔL-GFP 
(2)
VSV-9.1(+) 
(2)
VSV-G (San Juan, Indiana serotype) 
(1)
VSV-Indiana glycoprotein (G) 
(1)
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