Mikhail F. Alexeyev, PhD, University of South Alabama

Mikhail F Alexeyev, PhD
Mikhail F Alexeyev, PhD

The Alexeyev laboratory is interested in mitochondrial biology, mitochondrial disease, animal models of mitochondrial disease caused by mutations in mtDNA, mtDNA maintenance, replication, damage, repair, mutagenesis and manipulation.



  1. Spadafora D, Kozhukhar N, Alexeyev MF. Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number. PLoS One. 2016 Mar 31;11(3):e0152705.
  2. Shokolenko IN, Fayzulin RZ, Katyal S, McKinnon PJ, Wilson GL, Alexeyev MF. Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance. J Biol Chem. 2013 Sep 13;288(37):26594-605.
  3. Spadafora D, Kozhukhar N, Chouljenko VN, Kousoulas KG, Alexeyev MF. Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells. PLoS One. 2016 May 2;11(5):e0154684.
  4. Khozhukhar N, Spadafora D, Rodriguez Y, Alexeyev M. Elimination of Mitochondrial DNA from Mammalian Cells. Curr Protoc Cell Biol. 2018;78(1):20.11.1-20.11.14.
  5. Khozhukhar N, Spadafora D, Rodriguez YAR, Fayzulin R, Alexeyev M. Generation of Mammalian Cells Devoid of Mitochondrial DNA (ρ0 cells). Curr Protoc. 2023 Feb;3(2):e679. doi: 10.1002/cpz1.679. PMID: 36809687; PMCID: PMC10151036.