A*STAR Institute of Molecular and Cell Biology (IMCB) Monoclonal Antibody Unit

IMCB's Monoclonal Antibody Unit produces monoclonal antibodies for research, diagnostics and therapeutics applications. One of their focus areas is the use of monoclonal antibodies as tools to characterize and combat RNA viruses that can infect and cause severe diseases in human. Currently, MAU are working on the severe acute respiratory syndrome coronavirus (SARS-CoV), hepatitis C virus (HCV) and influenza A virus.



  1. Jude J Aweya; Ching Wooen Sze; Anthony Bayega; Nur Khairiah Mohd-Ismail; Lin Deng; Hak Hotta; Yee-Joo Tan. NS5B induces up-regulation of the BH3-only protein, BIK, essential for the Hepatitis C virus RNA replication and viral release. Virology. 2015 Jan 1;474:41-51.
  2. Barnwal B, Mok CK, Wu J, Diwakar MK, Gupta G, Zeng Q, Chow VT, Song J, Yuan YA, Tan YJ. A monoclonal antibody binds to threonine 49 in the non-structural 1 protein of influenza A virus and interferes with its ability to modulate viral replication. Antiviral Res. 2015 Apr;116:55-61.