Thomas M. Moran, PhD, Icahn School of Medicine at Mount Sinai

Thomas M. Moran, PhD
Thomas M. Moran, PhD

The Moran lab studies the interaction of the mammalian immune system with viral and bacterial pathogens. Studies using a mouse model of influenza virus infection have documented the kinetics and mechanisms by which the virus inhibits the initiation of immunity. Other studies have analyzed the interaction of influenza virus with dendritic cells, the key intermediaries between innate and adaptive immunity.

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References

  1. Bourmakina, S.V., and A. Garcia-Sastre. 2005. The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells. J Virol 79:7926-7932.
  2. Gannage, M., D. Dormann, R. Albrecht, J. Dengjel, T. Torossi, P.C. Ramer, M. Lee, T. Strowig, F. Arrey, G. Conenello, M. Pypaert, J. Andersen, A. Garcia-Sastre, and C. Munz. 2009. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe 6:367-380.
  3. Yondola, M.A., F. Fernandes, A. Belicha-Villanueva, M. Uccelini, Q. Gao, C. Carter, and P. Palese. Budding capability of the influenza virus neuraminidase can be modulated by tetherin. J Virol 85:2480-2491.
  4. Ramos, I., E. Carnero, D. Bernal-Rubio, C.W. Seibert, L. Westera, A. Garcia-Sastre, and A. Fernandez-Sesma. Contribution of Double-Stranded RNA and CPSF30 Binding Domains of Influenza Virus NS1 to the Inhibition of Type I Interferon Production and Activation of Human Dendritic Cells. J Virol 87:2430-2440.
  5. Hai, R., F. Krammer, G.S. Tan, N. Pica, D. Eggink, J. Maamary, I. Margine, R.A. Albrecht, and P. Palese. Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes. J Virol 86:5774-5781.
  6. Gao, Q., Y.Y. Chou, S. Doganay, R. Vafabakhsh, T. Ha, and P. Palese. The influenza A virus PB2, PA, NP, and M segments play a pivotal role during genome packaging. J Virol 86:7043-7051.
  7. Tan, G.S., F. Krammer, D. Eggink, A. Kongchanagul, T.M. Moran, and P. Palese. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol 86:6179-6188.
  8. O'Neill, R.E., J. Talon, and P. Palese. 1998. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J 17:288-296.
  9. Garcia-Sastre, A., R.K. Durbin, H. Zheng, P. Palese, R. Gertner, D.E. Levy, and J.E. Durbin. 1998. The role of interferon in influenza virus tissue tropism. J Virol 72:8550-8558.
  10. Gao, Q., A.C. Lowen, T.T. Wang, and P. Palese. A nine-segment influenza a virus carrying subtype H1 and H3 hemagglutinins. J Virol 84:8062-8071.
  11. Richards, K.A., F.A. Chaves, S. Alam, and A.J. Sant. Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins. Vaccine 31:219-225.
  12. Tan GS, Krammer F, Eggink D, Kongchanagul A, Moran TM, Palese P. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol. 2012 Jun;86(11):6179-88.