This mouse IgG2a monoclonal antibody [39E4] was generated against inactivated virus and specific for H1 hemagglutinin (HA) of influenza virus A/South Carolina/1/1918 (H1N1).
Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) outbreaks in 2009 as well as 1918. H1N1 is an orthomyxovirus because it contains the glycoproteins haemagglutinin and neuraminidase. Haemagglutinin causes red blood cells to clump together and binds the virus to the infected cell. In Neuraminidase are a type of glycoside hydrolase enzyme which help to move the virus particles through the infected cell and assist in budding from the host cells.
|Name:||1918 Influenza HA|
|Clone Name:||39 E4|
|Purification Method:||Protein G|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||ELISA, neutralization|
293T cells transfected with 3 ?g pCAGGS 1918 HA constructs. The blot was probed with an anti-1918 HA monoclonal antibody (39E4) and an anti-actin monoclonal antibody. Total cellular protein of 5 ?g, 2.5 ?g, or 1.25 ?g was loaded as indicated.
Adapted from: Glaser L. et al. J Virol. 2005 Sep;79(17):11533-6.
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