Brian J. Geiss, PhD, Colorado State University

Brian J. Geiss, PhD
Brian J. Geiss, PhD

A major focus of the Geiss laboratory is studying the biochemistry of flavivirus NS5 RNA capping enzyme. The capping enzyme is a multifunctional protein that forms the mature viral RNA cap that directs viral polyprotein translation and protects the viral genome from degradation.



  1. Terry JS, Anderson LB, Scherman MS, McAlister CE, Perera R, Schountz T, Geiss BJ. Development of SARS-CoV-2 Nucleocapsid Specific Monoclonal Antibodies. bioRxiv [Preprint]. 2020 Sep 3:2020.09.03.280370. doi: 10.1101/2020.09.03.280370. PMID: 32908982; PMCID: PMC7480041.
  2. Weger-Lucarelli J, Duggal NK, Bullard-Feibelman K, Veselinovic M, Romo H, Nguyen C, Rückert C, Brault AC, Bowen RA, Stenglein M, Geiss BJ, Ebel GD. Development and Characterization of Recombinant Virus Generated from a New World Zika Virus Infectious Clone. J Virol. 2016 Dec 16;91(1). pii: e01765-16. Print 2017 Jan 1. Erratum in: J Virol. 2017 Mar 29;91(8):. PubMed PMID: 27795432
  3. Geiss BJ, Shimonkevitz LH, Sackal CI, Olson KE. Recombination-ready Sindbis replicon expression vectors for transgene expression. Virol J. 2007 Oct 26;4:112.PubMed PMID: 17963504; PubMed Central PMCID: PMC2164957.