Howard A. Young, PhD, National Cancer Institute/NIH

Howard A. Young, PhD

The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, aplastic anemia and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.





  1. Blasi E, Radzioch D, Merletti L, Varesio L. Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus. Cancer Biochem Biophys. 1989;10(4):303‐317.
  2. Blasi E, Mathieson BJ, Varesio L, Cleveland JL, Borchert PA, Rapp UR. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature. 1985;318(6047):667‐670. 
  3. Xiao C, Wang RH, Lahusen TJ, et al. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012;287(50):41903‐41913.