Native Human Fibronectin and Vitronectin contain multiple domains of interaction, such as those for sulfated glycosaminoglycans, gelatin, fibrin, and cell surface integrin receptors, and for integrins, urokinase receptors, plasminogen activator inhibitor, and glycosaminoglycans, respectively.
The Hocking lab focuses on understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. Both structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin are studied. This information, in turn, is used to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
These two dozen Human Fibronectin and Vitronectin Domain Variants isolate the various binding sites on the proteins for specific study.
Part of The Investigator's Annexe program.