The Garcia-Sastre Laboratory is focused on exploring virus-host interactions with emphasis on virus regulation of innate and adaptive immune responses. The outcome of these interactions not only determines disease severity but also influences the development of protective immunity resulting from viral infection and/or vaccination. They have developed several techniques (reverse genetics), which allow for the genetic manipulation of the genomes of several virus families. These techniques are currently being used in several research areas including: i) characterization of virus-encoded virulence factors, ii) identification of virus-encoded antagonists of the interferon system, iii) virus replication and gene expression, iv) immune regulation of influenza replication, and v) vaccine development.
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