John C. Chrivia, PhD, St. Louis University

John C. Chrivia, PhD
John C. Chrivia, PhD

The Chrivia Lab studies the CREB-binding protein (CBP) as well as other related proteins such as SNF2-Related-CBP-Activator Protien (SRCAP). They found that SRCAP binds to a region within CBP shown to be important for CBP to function as a coactivator for CREB. Their current studies include both in vitro and in vivo approaches aimed at elucidating the mechanism(s) by which SRCAP regulates transcription.

The Investigator's Annexe Part of The Investigator's Annexe program.

Products

References

  1. Bowman TA, Wong MW, Cox LK, Baldassare JJ and Chrivia JC. Loss of H2A.Z is not sufficient to determine the transcriptional activity of SNF2-Related CBP Activator Protein (SRCAP) or p400 complexes. International Journal of Cell Biology . :715642. Epub 2011 May 29.
  2. The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. (2007). Wong, M.M., Cox L.K. and Chrivia, J.C. (2007). . J Biol Chem. 282, 26132-26139.
  3. Purification of a Human SRCAP Complex that Remodels Chromatin by Incorporating the Histone Variant H2A.Z into Nucleosomes. (2006). Ruhl, D.D., Jin, J. Cai, Y. Swanson, S., Florens, L., Michael P. Washburn, M.P., Conaway, R. and Conaway, J.W. and Chrivia, J.C.. Biochemistry 45, 5671-5677.