This antibody was raised in rabbits against a recombinant human protein of SRCAP corresponding to the C-terminal 200 amino acids. It is recommended for detection of human, mouse and rat SRCAP by WB.
The SRCAP (SNF2-Related-CBP-Activator Protein) gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features.
From the laboratory of John Chrivia, PhD, St. Louis University.
Part of The Investigator's Annexe program.
|Molecular Weight:||400 kDa|
|Reactivity:||Human, mouse, and rat|
|Epitope:||C-terminal 200 amino acids of SRCAP|
|Purification Method:||Crude serum|
|Buffer:||Normal rabbit serum|
|Tested Applications:||WB (1:1000-5000)|
Western Blot Analysis.
Western blot analysis of A549 nuclear extracts were performed using anti-p400 antibody (SLU3) or in the right panel using anti-SRCAP antibody (SLU2).
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