Scott D. Ryan, PhD, University of Guelph

Scott D. Ryan, PhD

The Ryan Lab strives to answer fundamental questions in neuroscience, develop new tools for collaborative investigation into the mechanisms underlying neurological disorders and train scientists in the areas of molecular neuroscience and stem cell biology.

 

Products

References

  1. Stykel, M.G., Humphries, K., Kirby, M.P., Czaniecki, C., Wang, T., Ryan, T., Bamm, V., Ryan, S.D. (2018). Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinsons disease. Faseb. J 32, 5350-5364. doi:10.1096/fj.201700759RR.
  2. ARyan, T., Bamm, V.V., Stykel, M.G., Coackley, C.L., Humphries, K.M., Jamieson-Williams, R., Ambasudhan, R., Mosser, D.D., Lipton, S.A., Harauz, G., et al. (2018). Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat. Commun 9, 1-17. doi:10.1038/s41467-018-03241-9.
  3. K.A. Vassall, V.V. Bamm, G. Harauz, MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis, Biochem. J. 472 (2015) 17-32.
  4. Bamm V.V., De Avila M., Smith G.S., Ahmed M.A., Harauz G. Structured functional domains of myelin basic protein: cross talk between actin polymerization and Ca(2+)-dependent calmodulin interaction. Biophys J. 101 (2011) 1248-56.
  5. Ahmed M.A., De Avila M., Polverini E., Bessonov K., Bamm V.V., Harauz G. Solution nuclear magnetic resonance structure and molecular dynamics simulations of a murine 18.5 kDa myelin basic protein segment (S72-S107) in association with dodecylphosphocholine micelles. Biochemistry. 51 (2012) 7475-87.
  6. Bamm, V. V., M. A. Ahmed, and G. Harauz. 2010. Interaction of myelin basic protein with actin in the presence of dodecyl phosphocholine micelles. Biochemistry. 49:6903-6915.
  7. Bates, I. R., Matharu, P., Ishiyama, N., Rochon, D., Wood, D. D., Polverini, E., Moscarello, M. A., Viner, N. J., and Harauz, G. (2000) Characterization of a Recombinant Murine 18.5-kDa Myelin Basic Protein. Protein Expression Purif. 20, 285-299.
  8. Smith G.S., Chen L, Bamm V.V., Dutcher J.R., Harauz G. The interaction of zinc with membrane-associated 18.5 kDa myelin basic protein: an attenuated total reflectance-Fourier transform infrared spectroscopic study. Amino Acids. 39 (2010) 739-750.
  9. Ahmed M.A., Bamm V.V., Harauz G., Ladizhansky V. Solid-state NMR spectroscopy of membrane-associated myelin basic protein--conformation and dynamics of an immunodominant epitope. Biophys J. 99 (2010) 1247-55.
  10. Vassall K.A., Jenkins A.D., Bamm V.V., Harauz G. Thermodynamic analysis of the disorder-to-&alpha-helical transition of 18.5-kDa myelin basic protein reveals an equilibrium intermediate representing the most compact conformation. J Mol Biol. 427 (2015) 1977-92.
  11. Vassall K.A., Bamm V.V., Jenkins A.D., Velte C.J., Kattnig D.R., Boggs J.M., Hinderberger D., Harauz G. Substitutions mimicking deimination and phosphorylation of 18.5-kDa myelin basic protein exert local structural effects that subtly influence its global folding. Biochim Biophys Acta. 1858 (2016) 1262-77.
  12. Bamm, V. V., M. A. Ahmed, and G. Harauz. Interaction of myelin basic protein with actin in the presence of dodecyl phosphocho- line micelles. Biochemistry. 49 (2010) 6903-6915.
  13. Zienowicz A., Bamm V.V., Vassall K.A., Harauz G. Myelin basic protein is a glial microtubule-associated protein - characterization of binding domains, kinetics of polymerization, and regulation by phosphorylation and a lipidic environment. Biochem Biophys Res Commun. 461 (2015) 136-41.
  14. Ryan, T., Bamm, V.V., Stykel, M.G., Coackley, C.L., Humphries, K.M., Jamieson-Williams, R., Ambasudhan, R., Mosser, D.D., Lipton, S.A., Harauz, G., et al. (2018). Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat. Commun 9, 1-17. doi:10.1038/s41467-018-03241-9.