Wild-type Alpha-synuclein protein.
Alpha-synuclein (&alpa;-synuclein) is an intrinsically disordered protein of unknown function that is linked to both familial and sporadic cases of Parkinson's disease, where it forms the major constituent of the pathological Lewy body aggregates. This peptide can be used for binding studies as well as for modelling Parkinson's via the generation of fibrils, which have been shown to seed endogenous α-synuclein inclusions in healthy cells.
From the laboratory of Scott D. Ryan, PhD, University of Guelph.
|Name:||recombinant human alpha-synuclein WT|
|Source:||Human, expressed in E. coli BL21 (DE3) CP+|
|Amino Acid Sequence:||MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA|
|Purity:||>95 %, purified by ion-exchange chromatography followed by reverse phase chromatography|
|Buffer:||10mM KPB pH 7.4|
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