Human α-Synuclein, WT (α-syn-WT)

Wild-type Alpha-synuclein protein.

Alpha-synuclein (&alpa;-synuclein) is an intrinsically disordered protein of unknown function that is linked to both familial and sporadic cases of Parkinson's disease, where it forms the major constituent of the pathological Lewy body aggregates. This peptide can be used for binding studies as well as for modelling Parkinson's via the generation of fibrils, which have been shown to seed endogenous α-synuclein inclusions in healthy cells.

From the laboratory of Scott D. Ryan, PhD, University of Guelph.

Catalog Number Product Size AVAILABILITY Price Qty
EGP017
Human α-Synuclein, WT (α-syn-WT)
1mg 1-2 weeks
Regular Price:$225.00
Specifications

Product Type: Protein
Name: recombinant human alpha-synuclein WT
Alternative Name(s): alpha-syn-WT
Accession ID: P37840
Source: Human, expressed in E. coli BL21 (DE3) CP+
Molecular Weight: 14,460.10
Amino Acid Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Fusion Tag(s): None
Purity: >95 %, purified by ion-exchange chromatography followed by reverse phase chromatography
Buffer: 10mM KPB pH 7.4
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Scott D. Ryan, PhD, University of Guelph.
References
  1. Ryan, T., Bamm, V.V., Stykel, M.G., Coackley, C.L., Humphries, K.M., Jamieson-Williams, R., Ambasudhan, R., Mosser, D.D., Lipton, S.A., Harauz, G., et al. (2018). Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat. Commun 9, 1-17. doi:10.1038/s41467-018-03241-9.
  2. Stykel, M.G., Humphries, K., Kirby, M.P., Czaniecki, C., Wang, T., Ryan, T., Bamm, V., Ryan, S.D. (2018). Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinsons disease. Faseb. J 32, 5350-5364. doi:10.1096/fj.201700759RR.

If you publish research with this product, please let us know so we can cite your paper.

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