Tom Misteli, PhD, National Cancer Institute/NIH

Tom Misteli
Tom Misteli, PhD

The Misteli laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.



  1. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T. Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol. 2007 Jun;9(6):675-82. Epub 2007 May 7.
  2. Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T. Spatial dynamics of chromosome translocations in living cells. Science. 2013 Aug 9;341(6146):660-4. doi: 10.1126/science.1237150.
  3. Roukos V, Burgess RC, Misteli T. Generation of cell-based systems to visualize chromosome damage and translocations in living cells. Nat Protoc. 2014 Oct;9(10):2476-92. doi: 10.1038/nprot.2014.167. Epub 2014 Sep 25.
  4. Burgess RC, Burman B, Kruhlak MJ, Misteli T. Activation of DNA damage response signaling by condensed chromatin. Cell Rep. 2014 Dec 11;9(5):1703-17.