Marvin J. Fritzler, MD, PhD, University of Calgary

Marvin J. Fritzler, MD, PhD
Marvin J. Fritzler, MD, PhD

Dr. Fritzler's research has focused on the identification of novel autoantigens that are the targets of the immune response in a number of autoimmune diseases including systemic lupus erythematosus, scleroderma, Sjogren's syndrome, idiopathic ataxia and rheumatoid arthritis. Dr Fritzler's discoveries have lead to the identification of a number of novel components of cell organelles (centromere, centrosome, mitotic spindle apparatus, Golgi complex, and endosome) and the recent identification of a new organelle referred to as GW bodies. These studies have lead to the development of new diagnostic assays and technologies for autoimmune diseases. Dr. Fritzler has also actively studied how drugs, chemicals (xenobiotics) and other environmental agents affect the immune system and initiate autoimmune diseases. This has lead to his seminal discovery that the primary target of drug-induced lupus is nuclear histones. In addition, he has studied the role of mercury in scleroderma and has conducted a number of population studies in Ft. McMurray, Swan Hills, Ft. Saskatchewan and Lake Wabamun with the sponsorship of the Department of Alberta Health and Wellness.

 

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References

  1. Selak S, Mahler M, Miyachi K, Fritzler ML, Fritzler MJ. Identification of the B-cell epitopes of the early endosome antigen 1 (EEA1). Clin Immunol 2003; 109:154-64.
  2. Selak S, Braun JE, Fritzler MJ. Characterization of early endosome antigen 1 in neural tissues. Biochem Biophys Res Commun 2004; 323:1334-42.
  3. Selak S, Fritzler MJ. Altered neurological function in mice immunized with early endosome antigen 1. BMC Neurosci 2004; 5:2.
  4. Selak S, Paternain AV, Fritzler MJ, Lerma J. Human autoantibodies against early endosome antigen-1 enhance excitatory synaptic transmission. Neuroscience 2006; 143:953-64.
  5. KJ Griffith, EKL Chan, JC Hamel, K Miyachi, MJ Fritzler. Molecular characterization of a novel 97 kDa Golgi complex autoantigen recognized by autoimmune antibodies from patients with Sjögren's syndrome. Arthritis Rheum. 40:1693-1702, 1997.
  6. K Nozawa, M J Fritzler, Y Takasaki, MR Wood, EKL. Chan. Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis. Cell Biol.Int. 33:148-157, 2009.
  7. Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel JC, Fritzler MJ, Chan EK. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol. 2005 Dec;7(12):1267-74.
  8. Sen GL, Blau HM. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat Cell Biol. 2005 Jun;7(6):633-6.
  9. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T. Identification of novel argonaute-associated proteins. Curr Biol. 2005 Dec 6;15(23):2149-55.
  10. Moser JJ, Fritzler MJ. Cytoplasmic ribonucleoprotein (RNP) bodies and their relationship to GW/P bodies. Int J Biochem Cell Biol. 2010 Jun;42(6):828-43.
  11. Li S, Wang L, Fu B, Berman MA, Diallo A, Dorf ME. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A. 2014 May 13;111(19):6970-5.
  12. Eystathioy T, Chan EK, Tenenbaum SA, Keene JD, Griffith K, Fritzler MJ. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol Biol Cell. 2002 Apr;13(4):1338-51.
  13. Eystathioy T, Chan EK, Mahler M, Luft LM, Fritzler ML, Fritzler MJ. A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182. Hybrid Hybridomics. 2003 Apr;22(2):79-86.
  14. Westendorf JM, Rao PN, Gerace L. Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Proc Natl Acad Sci USA 1994;91:714-8.
  15. Fritzler MJ, Kerfoot SM, Feasby TE, Zochodne DW, Westendorf JM, Dalmau JO et al. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein 1 (MPP-1). J Invest Med 2000;48:28-39.
  16. Matsumoto-Taniura N, Priollet F, Monroe R, Gerace L, Westendorf JM. Identification of novel M phase phosphoproteins by expression cloning. Mol Biol Cell 1996;7:1455-69.
  17. Abaza A, Soleilhac JM, Westendorf J, Piel M, Crevel I, Roux A et al. M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. J Biol Chem 2003;278:27844-52.