Dr. Fritzler's research has focused on the identification of novel autoantigens that are the targets of the immune response in a number of autoimmune diseases including systemic lupus erythematosus, scleroderma, Sjogren's syndrome, idiopathic ataxia and rheumatoid arthritis. Dr Fritzler's discoveries have lead to the identification of a number of novel components of cell organelles (centromere, centrosome, mitotic spindle apparatus, Golgi complex, and endosome) and the recent identification of a new organelle referred to as GW bodies. These studies have lead to the development of new diagnostic assays and technologies for autoimmune diseases. Dr. Fritzler has also actively studied how drugs, chemicals (xenobiotics) and other environmental agents affect the immune system and initiate autoimmune diseases. This has lead to his seminal discovery that the primary target of drug-induced lupus is nuclear histones. In addition, he has studied the role of mercury in scleroderma and has conducted a number of population studies in Ft. McMurray, Swan Hills, Ft. Saskatchewan and Lake Wabamun with the sponsorship of the Department of Alberta Health and Wellness.