This mouse IgG1 monoclonal antibody [4B6] was generated against recombinant protein and recognizes human and rabbit GW182.
GW bodies (GWBs) function as storage centers and degradation sites for mRNAs. GW182 is a cytoplasmic marker protein for GWBs that bids to mRNA. GW182 autoantigen, also designated EMSY interactor protein, plays a role in the maintenance and stability of the GWB structures. The GW182 protein has been shown to interact with endogenous argonaute-2 (Ago2), which is also enriched in GWBs. The GW182 protein is found in patients with ataxia, Sjoegren’s syndrome (SS) and sensor neuropathy disease by developing autoantibodies against GWB proteins.
From the laboratory of Marvin J. Fritzler, MD, PhD, University of Calgary.
Part of The Investigator's Annexe program.
|Alternative Name(s):||Rinucleotide repeat containing 6A, GW1; GW182; TNRC6; CAGH26|
|Molecular Weight:||182 kDa|
|Reactivity:||Human and rabbit|
|Buffer:||Cell culture supernatant|
|Tested Applications:||IF 1:10-1:50, WB Neat-1:10|
Sharma NR, Majerciak V, Kruhlak MJ, et al. KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. Nucleic Acids Res. 2019;47(17):9368-9385. View article
If you publish research with this product, please let us know so we can cite your paper.