Pavel A. Petukhov, PhD, University of Illinois at Chicago

Pavel A. Petukhov, PhD
Pavel A. Petukhov, PhD

Histone deacetylases (HDAC) comprise a family of enzymes that regulate chromatin remodeling, gene transcription, and activity of partner proteins. They control critical cellular processes, including cell growth, cell cycle regulation, DNA repair, differentiation, proliferation, and apoptosis. Chemical inhibitors of HDACs have been shown to inhibit tumor cell growth and induce differentiation and cell death.

The Petukhov lab has developed a set of photoreactive HDAC inhibitors suitable for photoaffinity labeling experiments. This allows for the identification of drug target proteins of biologically active compounds and mapping their binding sites.

The Investigator's Annexe Part of The Investigator's Annexe program.

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References

  1. Neelarapu, R., et al. Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes. Journal of Medicinal Chemistry. 54: 4350 - 4364. 2011.
  2. He, B., et al. Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the BindingPoses of HDAC8 Inhibitors.Journal of Medicinal Chemistry. 52(22): 7003 - 7013. 2009.