HDAC Photoreactive Inhibitor; V-91

V-91 is an azole-based compound which acts as a photoreactive histone deacetylase (HDAC) inhibitor suitable for photoaffinity labeling experiments. This allows for the identification of drug target proteins of biologically active compounds and mapping their binding sites.

Selectivity of V-91 for the active site of HDAC8 was demonstrated by blocking it with SAHA.

From the laboratory of Pavel A. Petukhov, PhD, University of Illinois at Chicago.

The Investigator's AnnexePart of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EB1001
HDAC Photoreactive Inhibitor; V-91
0.5mg In stock
Regular Price:$169.00
Specifications

Product Type: Small Molecule
Name: V-91
Chemical Formula: C22H26N8O4
Molecular Weight: 466.5
Format: solid
Purity: >95%, HPLC
Stability: > 6 months at -20C
Comments: Photoreactive group: arylazide; Activation wavelength: 280nm; Activation period: 3min
Storage: Store at -20C
Shipped: Cold Pack

Provider
From the laboratory of Pavel A. Petukhov, PhD, University of Illinois at Chicago.
Comments
Compound HDAC8 IC50 ± SD (nM)
SAHA 440 ± 2.1
V-91 734 ± 22

Adapted from Table 1; He, B., et al. Journal of Medicinal Chemistry, 52(22): 7003 - 7013. 2009.

References
  1. He, B., et al. Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the BindingPoses of HDAC8 Inhibitors.Journal of Medicinal Chemistry. 52(22): 7003 - 7013. 2009.

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