The King lab focuses on understanding the redox chemistry responsible for biological activity. To achieve these research goals, the lab uses a combination of synthetic and physical organic chemistry, biochemistry and biophysics to elucidate the identity, reactivity and effects of biological redox species. Much of their work centers on nitric oxide (NO) and the role it performs in biological systems. Specifically, they pursue the synthesis and evaluation of new organic compounds as HNO donors and the development of new organic-based methods of detection. As part of this study, they are attempting to better define the reactions of HNO with biological molecules, especially thiols and thiol-containing proteins and to understand biological pathways of HNO formation.
Part of The Investigator's Annexe program.