Martin Oppermann, MD, University Medical Center Gottingen

Martin Oppermann, MD
Martin Oppermann, MD

Professor Oppermann's research interests initially focused on immunoregulatory functions of the complement system, an important humoral element of innate immunity which consists of more than 20 soluble and membrane-bound proteins. Since 1996 his main research focus has been on chemokine receptors (CCR5, CXCR4) and their signalling mechanisms. These receptors are members of the GPCR superfamily, the largest known family of membrane proteins and certainly among the oldest devices devoted to cellular signalling. Chemokine receptors fulfil important roles in the homing and directed trafficking of immune cells to sites of inflammation. Importantly, these receptors also form entry ports for several pathogens, such as HIV-1/-2 (CCR5, CXCR4).

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References

  1. Oppermann, M., Baumgarten, H., Brandt, E., Gottsleben, W., Kurts, C., and Gotze, O. (1990) J. Immunol. Methods 133, 181-1902.
  2. Oppermann, M., Kurts, C., Zierz, R., Quentin, E., Weber, M. H., and Gotze, O. (1991) Kidney Int. 40, 939-947
  3. Oppermann, M., Hopken, U., and Gotze, O. (1992) Immunopharm. 24, 119-134
  4. Oppermann, M. and Gotze, O. (1994) Mol. Immunol. 31, 307-314
  5. Kaiser, J., Oppermann, M., Gotze, O., Deppisch, R., Gohl, H., Asmus, G., Rohrich, B., von Herrath, D., and Schaefer, K. (1994) Significant reduction of factor D and immunosuppressive complement fragment Ba byhaemofiltration.
  6. Wuzner, R., Schuff-Werner, P., Franzke, A., Nitze, R., Oppermann, M., Armstrong, V. W., Eisenhauer, T.,Seidel, D., and Goze, O. (1991) Eur. J. Clin. Invest. 21, 288-294
  7. Schuff-Werner, P., Schutz, E., Reitemeyer, F., Oppermann, M., Eisenhauer, T., Armstrong, V., Kostering, H.,Gotze, O., and Seidel, D. (1990) Heparin-induced extracorporeal LDL-precipitation (HELP): rheological, hemostaseological and immunological effects. In Gotto, A. M., Mancini, M., Richter, W. O., and Schwandt,P., editors. Treatment of severe hypercholesterolemia in the prevention of coronary heart disease, Basel,Karger
  8. Oppermann, M., Haubitz, M., Quentin, E., and Gotze, O. (1988) Klin. Wochenschr. 66, 857-864
  9. Puschel, G. P., Oppermann, M., Muschol, W., Gotze, O., and Jungermann, K. (1989) FEBS Lett. 243, 83-87
  10. Nezlin, R., Freywald, A., and Oppermann, M. (1993) Mol. Immunol. 30, 935-940
  11. Puschel, G. P., Hespeling, U., Oppermann, M., and Dieter, P. (1993) Hepatology 18, 1516-1521
  12. Elsner, J., Oppermann, M., Czech, W., Dobos, G., Schopf, E., Norgauer, J., and Kapp, A. (1994) C3aactivates oxygen radical species production and intracellular calcium transients in human eosinophils.
  13. Elsner, J., Oppermann, M., Czech, W., Schopf, E., and Kapp, A. (1994) Blood 83, 3324-3331
  14. Ammon, H. P. T., Ege, W., Oppermann, M., Gopel, W., and Eisele, S. (1995) Anal. Chem. 67, 466-471
  15. Puschel, G. P., Dieter, P., Muschol, W., Oppermann, M., Hulsmann, M., Schulze-Specking, A., Gotze, O.,Decker, K., and Jungermann, K. (1991) Prostanoid production in Kupffer cells: A step in the increase inglucose and lactate output and reduction of flow by anaphylatoxins in perfused rat liver. In Wisse, E.,Knook, D. L., and Decker, K., editors. Cells of the hepatic sinusoid, Leiden, Kupffer Cell Foundation
  16. Lhotta, K., Wurzner, R., Kronenberg, F., Oppermann, M., and Konig, P. (1998) Kidney Int. 53, 1044-1051
  17. Hopken, U., Struber, A., Oppermann, M., Mohr, M., Mucke, K. H., Burchardi, H., and Gotze, O. (1993)Production and characterization of peptide-specific monoclonal antibodies that recognize a neoepitope onhog C5a. In Faist, E., Meakins, J., and Schildberg, F. W., editors. Host defense dysfunction in trauma, shockand sepsis, Berlin,Heidelberg, Springer Verlag.
  18. Hopken, U., Mohr, M., Struber, A., Montz, H., Burchardi, H., Gotze, O., and Oppermann, M. (1996) Eur. J.Immunol. 26, 1103-1109
  19. Oppermann, M., Schulze, M., Gotze, O. (1991) A sensitive enzyme immunoassay for the quantitation ofhuman C5a/C5a(des Arg) anaphylatoxin using a monoclonal antibody with specificity for a neotope. Complement Inflamm. 8(1):13-24
  20. Mollnes et al. (1993) Clin Exp Immunol 91,295-300
  21. Scholl et al. (2008) PLoS ONE. 3(7):e2593
  22. F. Huttenrauch, B. Pollok-Kopp, M. Oppermann. G Protein- coupled receptor kinases promote phosphorylation and beta- arrestin-mediated internalization of CCR5 homo- and hetero- oligomers. J Biol Chem 280:37503 (2005)
  23. B. Pollok-Kopp, F. Huttenrauch, S. Rethorn, M. Oppermann. Dynamics of protein kinase C -mediated phosphorylation of the complement C5a receptor on serine-334 (Submitted)