Anti-Complement C5a/C5a (desArg) [C17/5] Antibody

This mouse IgG1k monoclonal antibody was generated against purified human complement C5a and recognizes human and baboon complement C5a/C5a (desArg).


  • Reacts with human and baboon C5a/C5a (desArg)
  • Useful as capture antibody in C5a ELISA
  • Blocks C5a biological activity
  • Suitable for Western Blot and ELISA applications

The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.

From the laboratory of Martin Oppermann, MD, University Medical Center Göttingen.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-Complement C5a/C5a (desArg) [C17/5] Antibody
100ug In stock
Regular Price:$355.00
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Product Type: Antibody
Antigen: Human C5a/C5a (desArg)
Accession ID: P01031
Isotype: IgG1k
Clonality: Monoclonal
Clone Name: C17/5
Reactivity: Human, baboon
Immunogen: Purified human C5a
Species Immunized: Mouse (Balb/c)
Epitope: Activation-dependent neo-epitope present on human C5a, but not C5
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB and ELISA
Storage: -20C
Shipped: Cold packs

Clone Reactivity Isotype Epitope Applications Functional Properties
M20/6 Human Ba / Factor B IgG1k N/A WB, ELISA, IP Detecting Ab in Ba ELISA (together with D22/3)
D22/3 Human Ba IgG2b/k Neo-Epitope on Ba (Glu215, Arg234) WB, ELISA, Flow Cytometry Capture Ab in Ba ELISA (together with M20/6)
I3/15 Human and baboon activated C3 IgG1k Neo-Epitope on C3b/iC3b/C3dg WB, ELISA Capture Ab in actC3 ELISA (together with rab anti-C3dg)
Z22/8 Porcine C3a/C3a(desArg) IgG2b/k Neo-Epitope on C3a/C3a(desArg) WB, ELISA, IP Capture Ab in C3a ELISA (together with K5/9); blocks C3a biological activity
K5/9 Porcine C3a/C3a(desArg) IgG1k N/A WB, ELISA Capture Ab in C3a ELISA (together with Z22/8); blocks C3a biological activity
G25/2 Human and baboon C5/C5a/C5a(desArg) IgG1k N/A WB, ELISA, IP Detecting Ab in C5a ELISA (together with C17/5); blocks C5a biological activity
C17/5 Human and baboon C5/C5a/C5a(desArg) IgG1k Neo-Epitope on C5a/C5a(desArg) WB, ELISA Capture Ab in C5a ELISA (together with G25/2); blocks C5a biological activity
T13/9 Porcine C5a/C5a(desArg) IgG1k Neo-Epitope on C5a (Tyr57- Gly74) WB, ELISA, IP Capture Ab in C5a ELISA (together with rab anti-C5a); blocks C5a biological activity
From the laboratory of Martin Oppermann, MD, University Medical Center Göttingen.
  1. Oppermann, M., Kurts, C., Zierz, R., Quentin, E., Weber, M. H., and Götze, O. (1991) Kidney Int. 40, 939-947
  2. Oppermann, M., Höpken, U., and Götze, O. (1992) Immunopharm. 24, 119-134
  3. Oppermann, M., Haubitz, M., Quentin, E., and Götze, O. (1988) Klin. Wochenschr. 66, 857-864
  4. Nezlin, R., Freywald, A., and Oppermann, M. (1993) Mol. Immunol. 30, 935-940
  5. Ammon, H. P. T., Ege, W., Oppermann, M., Göpel, W., and Eisele, S. (1995) Anal. Chem. 67, 466-471
  6. Püschel, G. P., Dieter, P., Muschol, W., Oppermann, M., Hülsmann, M., Schulze-Specking, A., Götze, O., Decker, K., and Jungermann, K. (1991) Prostanoid production in Kupffer cells: A step in the increase in glucose and lactate output and reduction of flow by anaphylatoxins in perfused rat liver. In Wisse, E., Knook, D. L., and Decker, K., editors. Cells of the hepatic sinusoid, Leiden, Kupffer Cell Foundation
  7. Lhotta, K., Würzner, R., Kronenberg, F., Oppermann, M., and Konig, P. (1998) Kidney Int. 53, 1044-1051
  8. Oppermann, M., Schulze, M., Götze, O. (1991) A sensitive enzyme immunoassay for the quantitation of human C5a/C5a(des Arg) anaphylatoxin using a monoclonal antibody with specificity for a neotope.Complement Inflamm. 8(1):13-24
  9. Mollnes et al. (1993) Clin Exp Immunol 91,295-300
  10. Scholl et al. (2008) PLoS ONE. 3(7):e2593

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