This mouse IgG2a monoclonal antibody [8G4-E8] was generated against a GST fusion protein corresponding to residues 576-796 of rat p130 Cas and is reactive against human, mouse and rat p130 Cas.
Breast cancer anti-estrogen resistance protein 1 (BCAR1, p130 Cas) is ubiquitously expressed adapter protein belonging to the Cas family. It can act as a docking protein containing multiple protein-protein interaction domains and used by many signalling partners. Due to its ability to associate with many signaling partners, p130 Cas/BCAR1 has been shown to play a key role in cell adhesion, migration, apoptosis, hypoxia and mechanical forces. Over expression of p130 Cas/BCAR1 has been identified in several cancer types including breast cancer.
Part of The Investigator's Annexe program.
|Accession ID:||NM 014567|
|Molecular Weight:||130 kDa|
|Reactivity:||Human, mouse and rat|
|Immunogen:||GST fusion protein corresponding to residues 576-796 of rat p130 Cas|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, IF, IP|
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