Amy H. Bouton, PhD, University of Virginia
Amy H. Bouton, PhD
The Bouton research group has been studying molecular mechanisms by which breast cancer cells become resistant to the growth-inhibitory effects of antiestrogens. This is a significant problem in breast cancer treatment, since as many as 50% of breast tumors never respond to antiestrogen therapy (intrinsic resistance), and the majority of tumors that initially respond acquire resistance to these drugs over time (acquired resistance). Their work in this area is focused on understanding how overexpression of two proteins, the adapter molecule Cas and one of its binding partners AND-34, confer resistance to antiestrogens such as tamoxifen.
Part of The Investigator's Annexe program.
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References
- Bouton AH, Burnham MR. Detection of distinct pools of the adapter protein p130CAS using a panel of monoclonal antibodies. Hybridoma. 1997 Oct;16(5):403-11.
