This IgG2a mouse monoclonal antibody [1B3B9] was generated against HPLC purified murine recombinant mitogen-activated protein kinase 1 (MAPK1) and is reactive against avian, human, mouse and rat MAP kinase 1/Extracellular signal-regulated kinase2 (ERK2).
ERK2 is activated by mitogen-activated protein kinase 2 (MEK2), which phosphorylates neighboring threonine 183 and tyrosine 185 residues. ERK2 is a serine/threonine kinase that phosphorylates MAP2 and myelin basic protein. This kinase is an important proximal component of the MAP kinase pathway involved in transmitting the signals from growth factors, neurotransmitters and hormones at the cell surface to the transcriptional events in the nucleus.
From the laboratory of Michael J. Weber, PhD, University of Virginia.
Part of The Investigator's Annexe program.
|Alternative Name(s):||Mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP2K2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MP2K2; PRKMK2|
|Antigen:||MAP Kinase 1/ERK2|
|Molecular Weight:||42 kDa|
|Reactivity:||Avian, mouse, rat and human|
|Immunogen:||HPLC purified murine recombinant MAP Kinase|
|Purification Method:||Protein G Affinity Chromatography|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
At low concentration, preferentially reacts with unphosphorylated enzyme.
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