Anti-PLSCR1 [4D2] Hybridoma
![Anti-PLSCR1 [4D2] Hybridoma](https://www.kerafast.com/MediaStorage/Product/Images/Large/910_200120200126269090.jpg "Anti-PLSCR1 [4D2] Hybridoma")
This hybridoma line constitutively produces a human phospholipid scramblase 1 (PLSCR1) monoclonal antibody [clone 4D2].
Highlights:
- Specific for human phospholipid scramblase 1 (PLSCR1)
- Suitable for Western Blot and Immunohistochemistry applications
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding protein that has been implicated in the transbilayer movement of plasma membrane phospholipids (PLs). PLSCR1 potentially functions to redistribute membrane PLs that play a central role in activation of complement, coagulation systems, and in recognition and phagocytic clearance of injured, aged or apoptotic cells. Four human PLSCR genes (HuPLSCR1–4) have been identified which are conserved through evolution.
From the laboratory of Peter J. Sims, MD, PhD, Blood Center of Wisconsin
Part of The Investigator's Annexe program.
This hybridoma line constitutively produces a human phospholipid scramblase 1 (PLSCR1) monoclonal antibody [clone 4D2].
Highlights:
- Specific for human phospholipid scramblase 1 (PLSCR1)
- Suitable for Western Blot and Immunohistochemistry applications
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding protein that has been implicated in the transbilayer movement of plasma membrane phospholipids (PLs). PLSCR1 potentially functions to redistribute membrane PLs that play a central role in activation of complement, coagulation systems, and in recognition and phagocytic clearance of injured, aged or apoptotic cells. Four human PLSCR genes (HuPLSCR1–4) have been identified which are conserved through evolution.
From the laboratory of Peter J. Sims, MD, PhD, Blood Center of Wisconsin
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | PLSCR1 |
| Accession ID: | O15162 |
| Molecular Weight: | 35.049 kDa |
| Isotype: | IgG |
| Clone Name: | 4D2 |
| Reactivity: | Human |
| Growth Conditions: | RPMI + 15% heat inactivated donor equine serum + antibiotics |
| Species Immunized: | Mouse |
| Cryopreservation: | Growth medium + 10% DMSO |
| Tested Applications: | WB (2ug/mL), IHC (20 ug/mL) |
| Storage: | Liquid nitrogen |
| Shipped: | Dry ice |
- Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ. Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha. J Biol Chem. Blood. 2000 Apr 15;95(8):2593-9.
- Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ.c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1. J Biol Chem. 2001 Aug 3;276(31):28984-90.
- Zhou Q, Zhao J, Wiedmer T, Sims PJ. Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1. Blood. 2002 Jun 1;99(11):4030-8.
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