Anti-NOX2/gp91phox [NL7] Antibody
![Anti-NOX2/gp91phox [NL7] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/846_200120200126248450.jpg "Anti-NOX2/gp91phox [NL7] Antibody")
This IgG1 mouse mononoclonal antibody was generated against the partially purified human neutrophil flavocytochrome b (cytochrome b559 or cytochrome b558) and is reactive against human gp91phox amino acids 498-506.
Gp91phox (portion of the heterodimer Cytochrome b) is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. Defects in the CYBB gene are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide and patients suffer from life-threatening bacterial/fungal infections.
From the laboratory of Algirdas J. Jesaitis, PhD, Montana State University.
Part of The Investigator's Annexe program.
This IgG1 mouse mononoclonal antibody was generated against the partially purified human neutrophil flavocytochrome b (cytochrome b559 or cytochrome b558) and is reactive against human gp91phox amino acids 498-506.
Gp91phox (portion of the heterodimer Cytochrome b) is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. Defects in the CYBB gene are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide and patients suffer from life-threatening bacterial/fungal infections.
From the laboratory of Algirdas J. Jesaitis, PhD, Montana State University.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Name: | Anti-NOX2/gp91phox [NL7] Antibody |
| Accession ID: | P04839 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | NL7 |
| Reactivity: | Human |
| Specificity: | Human gp91phox ? 498-EKDVITGRKQ-507 |
| Immunogen: | Partially purified human neutrophil flavocytochrome b (heparin Ultrogel/lectin affinity purification ? in Triton X-100) |
| Species Immunized: | Mouse |
| Myeloma Used: | P3U1 |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB (1:1000) |
| Storage: | -20C |
| Shipped: | Cold packs |
- Burritt,J.B., Foubert, T.R., Baniulis, D., Lord, C.L., Taylor, R.M., Mills, J.S., Roos, D., Parkos, C.A. and Jesaitis, A.J. Functional epitope on human neutrophil flavocytochrome b558. J.Immunol. 170:6082-6089. 2003.
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