This mouse IgM monoclonal antibody was generated against human rheumatoid synovial T cell line (ST-1). It has been classified as recognizing the CD60 structure on a T cell subset and on various other cells, such as stromal cells in thymus and synovium. The antibody recognizes a carbohydrate-dependent epitope on proteins of 92 and 70 kDa, and also binds to the 9-O-acetylated GD3 ganglioside.
CD60b (formally called CDw60) is a 9-O-acetylated form of GD3 ganglioside. The CD60b antigen is expressed on peripheral blood T cells, monocytes, platelets, synovial fibroblasts and some cell lines. Cytotoxic T cells, T helper cells and IL-4-producing cells are the T cell subsets that express CD60b. It is hypothesized that CD60b may provide costimulatory signals for T cells. After stimulation of naive CD45RA+ T cells, the CD60b antigen is upregulated, corresponding with the switch from CD45RA+ to CD45RO+. CD34+ hemato-poietic precursor cells have been shown to be CD60b positive.
From the laboratory of David A. Fox, MD, University of Michigan.
Part of The Investigator's Annexe program.
|Molecular Weight:||92/70 kDa|
|Immunogen:||RA synovial T cells|
|Tested Applications:||Flow Cytometry, IP, WB|
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