The main objectives of the Letarte lab are to understand the function of endoglin and to characterize the endothelial cell pathways altered in Hereditary hemorrhagic telangiectasia (HHT). They discovered endoglin, the gene coding for a glycoprotein of 180 kDa expressed at high levels on the endothelium of all blood vessels. They also showed that endoglin is a co-receptor for TGF-Ã? and the gene mutated in HHT type 1 (HHT1).
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