Michelle Letarte, PhD, Hospital for Sick Children

Michelle Letarte , PhD
Michelle Letarte, PhD

The main objectives of the Letarte lab are to understand the function of endoglin and to characterize the endothelial cell pathways altered in Hereditary hemorrhagic telangiectasia (HHT). They discovered endoglin, the gene coding for a glycoprotein of 180 kDa expressed at high levels on the endothelium of all blood vessels. They also showed that endoglin is a co-receptor for TGF-Ã? and the gene mutated in HHT type 1 (HHT1).

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  1. Quackenbush EJ, Letarte M. Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies. J Immunol. 1985 Feb;134(2):1276-85.
  2. Quackenbush EJ, Gougos A, Baumal R, Letarte M. Differential localization within human kidney of five membrane proteins expressed on acute lymphoblastic leukemia cells. J Immunol. 1986 Jan;136(1):118-24.
  3. Cheifetz S, Bellón T, Calés C, Vera S, Bernabeu C, Massagué J, Letarte M. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem. 1992 Sep 25;267(27):19027-30.
  4. Gougos A, Letarte M. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem. 1990 May 25;265(15):8361-4.
  5. Gougos A, St Jacques S, Greaves A, O'Connell PJ, d'Apice AJ, Bühring HJ, Bernabeu C, van Mourik JA, Letarte M. Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts. Int Immunol. 1992 Jan;4(1):83-92.