This IgG2a mouse antibody was generated against amino acids 436-450 of beta tubulin type III and recognizes mammalian homologs.
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.
Class III beta-tubulin (TUBB3) is a microtubule element expressed exclusively in neurons, and is a popular identifier specific for neurons in nervous tissue. TUBB3 plays a critical role in proper axon guidance and maintenance.
From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
|Name:||Anti-Class III Beta Tubulin (Tubb3); clone AA10|
|Specificity:||Class III Beta Tubulin (all mammalian homologs)|
|Immunogen:||Generated against amino acids 436-450 of Class III Beta Tubulin|
|Purification Method:||Protein G affinity purified|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, IHC, IP, IF|
|Storage:||Store at 4C|
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