The Benevolenskaya lab is studying the mechanisms that orchestrate the initiation and progression of cell differentiation using both traditional methods and high-throughput approaches. Dr. Benevolenskaya's research plans are aimed at understanding how, by positive or negative regulation of transcription, RBP2 and other pRB-interacting proteins affect differentiation. These studies will shed light on how pRB cooperates with cell-fate determining transcription factors, which is a poorly understood tumor suppressor function of pRB. If we reach global understanding of the central effectors of pRB involved in transcriptional regulatory interactions, we will know how to manipulate it to treat cancer.
Part of The Investigator's Annexe program.