This mouse monoclonal IgG3 antibody, MARCO [PLK1], was raised against human alveolar macrophages (AMs) and recognises the extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples.
Macrophage Receptor With Collagenous Structure (MARCO) is encoded by MARCO gene, and is a member of the class A scavenger receptor family. This transmembrane protein is found in certain subtypes of macrophages and plays a key role in innate immune tolerance by scavenging or clearing the pathogens and thus leading to inflammatory responses (mediates binding of unopsonized particles by alveolar macrophages). MARCO is associated with several diseases, such as Alzheimer's disease, Igg4-Related Disease and Bacterial Pneumonia. It has also been studied in oncology as a potentially attractive target for immunotherapy.
From the laboratory of Lester Kobzik, MD , Harvard University.
|Name:||Anti-MARCO [PLK1] Antibody|
|Alternative Name(s):||macrophage receptor MARCO; macrophage receptor with collagenous structure; scavenger receptor class A member 2; SCARA2|
|Reactivity:||Human and bovine MARCO|
|Specificity:||Extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples|
|Immunogen:||Human Alveolar Macrophages|
|Species Immunized:||Mouse, BALB/c|
|Epitope:||Extracellular domain V between residues 420 and 431|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||Flow Cytometry, IP, WB, IF, IHC-Fr|
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