Human embryonic kidney 293 (HEK293) cells with a complete deletion of the Sirtuin 1 (SIRT1) gene.
SIRT1 is the most conserved mammalian NAD+-dependent protein deacetylase and an important cellular metabolic and stress sensor. Through deacetylation of transcription factors and co-factors critically involved in metabolic homeostasis, inflammatory responses, and stress resistance, SIRT1 directly couples cellular metabolic status (via NAD+) to transcriptional reprogramming in response to environmental changes.
From the laboratory of Xiaoling Li, PhD, National Institute of Environmental Health Sciences/NIH.
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|Product Type:||Cell Line|
|Name:||HEK293T SIRT1 KO|
|Cell Type:||Human embryonic kidney cells|
|Organism:||Homo sapiens, human|
|Biosafety Level:||BSL 2|
|Growth Conditions:||DMEM + 10% FBS|
|Subculturing:||Adherent, 1:3 to 1:12 dilution|
|Cryopreservation:||Complete growth medium supplemented with 10% DMSO|