Anti-Bacillus subtilis CodY Antibody

This rabbit polyclonal antibody was generated against purified Bacillus subtilis GTP-sensing transcriptional pleiotropic repressor CodY and is specific for CodY from B. subtilis.

Highlights:

  • Reacts with CodY from B. subtilis
  • Suitable for Western Blot applications

CodY (VEG286B) is a DNA-binding protein found in most low G+C Gram-positive bacteria that activates the expression of some genes that support rapid growth and represses the expression of many genes that are only induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is activated as a DNA-binding protein by interaction with a branched-chain amino acid (isoleucine or leucine or valine) and GTP; these metabolites serve as indicators of nutritional sufficiency for rapid growth. As the concentrations of the metabolites drop, CodY loses its ability to bind DNA as either a negative or positive regulator.

From the laboratory of Abraham L Sonenshein, PhD, Tufts University.

Catalog Number Product Size AVAILABILITY Price Qty
ETU005
Anti-Bacillus subtilis CodY Antibody
100uL In stock
Regular Price:$299.00
Specifications

Product Type: Antibody
Antigen: CodY
Accession ID: P39779
Molecular Weight: 29,013 Da
Isotype: IgG
Clonality: Polyclonal
Reactivity: Recognizes Bacillus subtilis CodY
Immunogen: Purified Bacillus subtilis CodY
Species Immunized: Rabbit
Buffer: Whole serum
Tested Applications: WB 1:5000
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Abraham L Sonenshein, PhD, Tufts University.
References
  1. Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL. Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes Dev. 2001 May 1;15(9):1093-103.
  2. Basu A, Shields KE, Eickhoff CS, Hoft DF, Yap MN. Thermal and Nutritional Regulation of Ribosome Hibernation in Staphylococcus aureus. J Bacteriol. 2018 Nov 26;200(24). View Article

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