Abraham L Sonenshein, PhD, Tufts University

Abraham L Sonenshein, PhD
Abraham L Sonenshein, PhD

The Sonenshein lab studies the regulation of gene transcription in spore-forming bacteria (Bacillus subtilis and Clostridium difficile) and related Gram-positive bacteria. The key questions under investigation are the nutritional signals that the cell senses as an indication that it must move from active growth to differentiation and the molecular mechanisms by which these signals are used to control expression of specific stationary phase, sporulation and virulence genes. The potential roles of transcription factors and the spores themselves as virulence factors are being investigated for the case of antibiotic-associated colitis caused by C. difficile.

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References

  1. Serio AW, Sonenshein AL. Expression of yeast mitochondrial aconitase in Bacillus subtilis. J Bacteriol. 2006 Sep;188(17):6406-10.
  2. Pechter KB, Meyer FM, Serio AW, Stülke J, Sonenshein AL. Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis. J Bacteriol. 2013 Apr;195(7):1525-37. doi: 10.1128/JB.01690-12.
  3. Vincent CD, Friedman JR, Jeong KC, Buford EC, Miller JL, Vogel JP. Identification of the core transmembrane complex of the Legionella Dot/Icm type IV secretion system. Mol Microbiol. 2006 Dec;62(5):1278-91. Epub 2006 Oct 16.
  4. Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL. Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes Dev. 2001 May 1;15(9):1093-103.