pCS2-SENP2(L)Neo plasmid is a vector encoding th Senp2 gene for SUMO-specific protease 2 and the neomycin gene.
pCS2-SENP2(L) is a plasmid containing cDNA which encodes the long isoform of myc tagged SENP2. The expression is driven by CMV promoter. SENP2 encodes SUMO-specific protease 2 which is found in three alternatively spliced forms exhibiting differential subcellular localizations. Genetic inactivation of Senp2 in mice reveals its requirement in development of trophoblast stem cell niches and lineages during development of the placenta. The deletion of SENP2 in the neural progenitors results in neural degeneration mediated through modulation of Drp1-dependent mitochondrial morphogenesis.
From the laboratory of Wei Hsu, PhD, University of Rochester.
|Fusion Tag(s):||Myc tag|
|Grow in E. coli at 37 C:||Yes|
|Cloning Site 5':||Xho l|
|Cloning Site 3':||Xba I|
|Insert Size:||SENP2: 13.9 Kb and pgk-Neo: 2 kb|
|Vector Backbone and Size:||4352 Kb|
|High or low copy:||High|
|Shipped:||Ambient temperature as liquid|
CMV driven expression of SENP2 long isoform.
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