Edward Perez-Reyes, PhD, University of Virginia

Edward Perez-Reyes, PhD
Edward Perez-Reyes, PhD

The major contribution of the Perez-Reyes laboratory has been on the molecular physiology and pharmacology of voltage-gated calcium channels, and in particular, the cloning of low voltage-activated T-type calcium channels. These recombinant channels were then stably expressed in HEK-293 cells, and then validated by patch clamp electrophysiology and high throughout Calcium-based assays (Xie et al. 2007). Novel T-type channel blockers have been developed that show efficacy in animal models of absence epilepsy and neuropathic pain.



  1. Xie X, Van Deusen AL, Vitko I, Babu DA, Davies LA, Huynh N, Cheng H, Yang N,Barrett PQ, Perez-Reyes E. Validation of high throughput screening assays againstthree subtypes of Ca(v)3 T-type channels using molecular and pharmacologicapproaches. Assay Drug Dev Technol. 2007 Apr;5(2):191-203.
  2. Perez-Reyes, E., Van Deusen, A., Vitko, I. Molecular Pharmacology of Human Cav3.2 T-Type Ca2+ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs. JPET 328:621-7, 2009.
  3. Gomora JC, Murbartián J, Arias JM, Lee JH, Perez-Reyes E. Cloning andexpression of the human T-type channel Ca(v)3.3: insights into prepulsefacilitation. Biophys J. 2002 Jul;83(1):229-41.