Anti-Beta-Spectrin Antibody

This rabbit IgG polyclonal antibody was generated against purified human red blood cell spectrin beta-chain monomer and is specific for human red blood cell beta-spectrin.

Highlights:

  • Reacts with human red blood cell beta-spectrin
  • Recommended for Western Blot applications

Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells along with actin. Spectrin plays a role in cell shape control, arrangement of transmembrane proteins, and organelle positioning. Beta-Spectrin functions as a structural element and stabilizes erythrocyte membranes. Mutations in beta-spectrin are described as a possible cause of neonatal hemolytic anemia, spherocytosis type 2, and hereditary elliptocytosis.

From the laboratories of David W. Speicher, PhD, The Wistar Institute.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EWI030
Anti-Beta-Spectrin Antibody
50uL In stock
Regular Price:$306.00
On Sale:
Specifications

Product Type: Antibody
Alternative Name(s): Beta-I spectrin, Spectrin beta chain, erythrocytic
Accession ID: HGNC: 11274 Entrez Gene: 6710 Ensembl: ENSG00000070182 OMIM: 182870 UniProtKB: P11277
Antigen: Human Red Blood Cell beta-Spectrin
Molecular Weight: 246 kDa
Isotype: IgG
Clonality: Polyclonal
Reactivity: Human
Immunogen: Purified human red blood cell spectrin beta-chain monomer
Species Immunized: Rabbit
Purification Method: Rabbit serum
Tested Applications: Western Blot (1:500,000; 10sec exposure)
Storage: -80C
Shipped: Dry ice

Data

Western Blot

Lane 1, Human Melanoma (1205 LU); Lane 2, Human Ovarian Cancer (RMG1); Lane 3, Human Ovarian Cancer (OV90); Lane 4, Human Red Cell Membrane. Gel loads: Lanes 1-3, 25mg; Lane 4, 0.5mg. Antibody dilution: 1:500,000, 10sec exposure.

Provider
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
References
  1. Shih IM, Speicher D, Hsu MY, Levine E, Herlyn M. Melanoma cell-cell interactions are mediated through heterophilic Mel-CAM/ligand adhesion. Cancer Res. 1997 Sep 1;57(17):3835-40.

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