This rabbit IgG polyclonal antibody was generated against purified human red blood cell spectrin beta-chain monomer and is specific for human red blood cell beta-spectrin.
Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells along with actin. Spectrin plays a role in cell shape control, arrangement of transmembrane proteins, and organelle positioning. Beta-Spectrin functions as a structural element and stabilizes erythrocyte membranes. Mutations in beta-spectrin are described as a possible cause of neonatal hemolytic anemia, spherocytosis type 2, and hereditary elliptocytosis.
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
|Alternative Name(s):||Beta-I spectrin, Spectrin beta chain, erythrocytic|
|Accession ID:||HGNC: 11274 Entrez Gene: 6710 Ensembl: ENSG00000070182 OMIM: 182870 UniProtKB: P11277|
|Antigen:||Human Red Blood Cell beta-Spectrin|
|Molecular Weight:||246 kDa|
|Immunogen:||Purified human red blood cell spectrin beta-chain monomer|
|Purification Method:||Rabbit serum|
|Tested Applications:||Western Blot (1:500,000; 10sec exposure)|
Lane 1, Human Melanoma (1205 LU); Lane 2, Human Ovarian Cancer (RMG1); Lane 3, Human Ovarian Cancer (OV90); Lane 4, Human Red Cell Membrane. Gel loads: Lanes 1-3, 25mg; Lane 4, 0.5mg. Antibody dilution: 1:500,000, 10sec exposure.
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