Anti-Filamin-A Antibody

This rabbit IgG polyclonal antibody was generated against human smooth muscle filamin purified from smooth muscle and is specific for human smooth muscle filamin, filamin A.

Highlights:

  • Reacts with human filamin A
  • Recommended for Western Blot applications

The smooth muscle filamin ( Filamin A) gene encodes an actin-binding protein that joins actin filaments and links actin filaments to membrane glycoproteins. Filamin A is involved in remodeling the cytoskeleton changing cell shape and aiding in migration. Filamin A interacts with integrins, transmembrane receptor complexes, and second messengers. Mutations in Filamin A result in periventricular nodular heterotopias (PVNH1, PVNH4), Melnick-Needles syndrome (MNS), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX).

From the laboratories of David W. Speicher, PhD, The Wistar Institute.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EWI033
Anti-Filamin-A Antibody
100uL In stock
Regular Price:$306.00
On Sale:
Specifications

Product Type: Antibody
Alternative Name(s): Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1,Non-muscle filamin
Accession ID: HGNC: 3754 Entrez Gene: 2316 Ensembl: ENSG00000196924 OMIM: 300017 UniProtKB: P21333
Antigen: Human Smooth Muscle Filamin, Filamin A
Isotype: IgG
Clonality: Polyclonal
Reactivity: Human
Immunogen: Human Smooth Muscle Filamin Purified from Smooth Muscle
Species Immunized: Rabbit
Purification Method: Affinity Purified using Human Smooth Muscle Filamin
Tested Applications: Western Blot (1:2,000; 20sec exposure)
Storage: -80C
Shipped: Dry ice

Data

Western Blot

Lane 1, Human Red Cell Membrane; Lane 2, Human Ovarian Cancer (OVCAR3); Lane 5, Human Ovarian Cancer (OV90). Gel loads: Lane 1, 5mg; Lanes 2, 25mg. Antibody dilution: 1:2,000, 20sec exposure.

Provider
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
References
  1. Hock RS, Davis G, Speicher DW. Purification of human smooth muscle filamin and characterization of structural domains and functional sites. Biochemistry. 1990 Oct 9;29(40):9441-51.

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