James M. Ervasti, PhD, University Minnesota, Twin Cities
James M. Ervasti, PhD
The Ervasti laboratory objective is to fully define the function of dystrophin in striated muscle to understand how its absence or abnormality leads to the pathologies observed in Duchenne and Becker muscular dystrophies. Their unique approach integrates biochemical and biophysical analyses of the very large dystrophin protein with in vivo assessments of its function in transgenic mouse models of muscular dystrophy.
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References
- Patrinostro X, O'Rourke AR, Chamberlain CM, Moriarity BS, Perrin BJ, Ervasti JM. Relative importance of β(cyto)- and γ(cyto)-actin in primary mouse embryonic fibroblasts. Mol Biol Cell. 2017 Mar 15;28(6):771-782.
