The Fox laboratory was one of the first to identify and characterize the metalloproteinases present in numerous snake venoms. Their research has elucidated the structures of these toxins and identified the biochemical and cellular mechanisms by which the toxins function to give rise to their noted pathologies. Specifically their research interests have been centered on metalloproteinases and extracellular matrix and the processes they regulate in normal and pathological circumstances. Their recent focus has expanded to include the interaction of host and tumor in carcinogenesis and metastasis and the role of stromal microenvironment, inflammation in cancer metastasis and invasion. They are also carrying out research on the discovery and validation of biomarkers associated with normal and chronic wound healing.