The Satchi-Fainaro Laboratory research aims to advance the field of vascular biology and the development of vascular targeting nanomedicines is by: (1) Characterization of tumor vasculature for tailored-made therapy. Identifying new molecular markers on tumor endothelial cells in order to develop better drugs and better targeting moieties. (2) Design of novel nanocarriers as strategies to target angiogenesis inhibitors to tumor vasculature. To improve the therapeutic index of chemotherapeutic and antiangiogenic agents by conjugation to polymeric nanocarriers. (3) Investigation of the mechanism of action of angiogenesis inhibitors (endogenous and pharmacological inhibitors). (4) Intravital non-invasive molecular imaging of treated tumor-bearing mice to follow tumor progression, pharmacodynamics and pharmacokinetics of the synthesized nanomedicines. (5) Shedding light on the molecular basis of tumor dormancy using polymer therapeutics.