Sheldon Park, PhD, University at Buffalo

Sheldon Park, PhD
Sheldon Park, PhD

The Park Laboratory uses computational and experimental tools to design protein molecules for use in research, medicine and biotechnology. Most commonly used tools in the lab include homology modeling, rational design, and directed evolution by yeast display. The designed molecules are characterized in vitro using biochemical and biophysical techniques and, where applicable, tested in cellular systems to demonstrate function. The current projects include engineering and application of monomeric streptavidin, monobody and peptide inhibitors, and split inteins.

The Investigator's Annexe Part of The Investigator's Annexe program.



  1. Lim, K.H., Huang, H., Pralle, A., and Park, S. Stable, High-Affinity Streptavidin Monomer for Protein Labeling and Monovalent Biotin Detection. Biotechnology Bioeng 110, 57-67 (2013)
  2. DeMonte, D., Drake, E., Lim, K.H., Gulick, A., Park, S., Structure based engineering of streptavidin monomer with a reduced biotin dissociation rate. Proteins: Structure, Function, and Bioinformatics (DOI: 10.1002/prot.24320)