Li Cai, PhD, Rutgers University

Li Cai, PhD
Li Cai, PhD

The Cai lab focuses on the genetic mechanisms that regulate gene expression of stem cells in both normal development and tumorigenesis. They are using integrative computational and experimental approaches to identify, verify and characterize the genetic regulatory elements, e.g., the conserved non-coding DNA sequences and their interacting protein factors that involved in the regulation of stem cell gene expression. A thorough understanding of these mechanisms will provide the knowledge of stem cell development into various normal cell types as a repair system for the body, as well as a basis for the therapeutic treatments of cancers.

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References

  1. Islam MM, Li Y, Luo H, Xiang M, Cai L. Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation. Biol Open. 2013 Sep 6;2(11):1125-36.
  2. Smith SM, Cai L. Cell Specific CD44 Expression in Breast Cancer Requires the Interaction of AP-1 and NFkB with a Novel cis-Element. (2012) PLoS ONE 7(11): e50867.
  3. Tzatzalos E, Smith SM, Doh ST, Hao H, Li Y, Wu A, Grumet M, Cai L. A cis-element in the Notch1 locus is involved in the regulation of gene expression in interneuron progenitors. Dev Biol. 2012 Dec 15;372(2):217-28.