Lamprey GnRH-II Peptides

Synthetic peptides corresponding to Lamprety gonadotropin realeasing hormone (GnRH)-II.

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.

From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.

Catalog Number Product Size AVAILABILITY Price Qty
EUN010
Lamprey GnRH-II, wild-type (pGlu-His-Trp-Ser-His-Gly-Trp-Phe-Pro-Gly), 250ug
250ug In stock
Regular Price:$150.00
EUN011
Lamprey GnRH-II, extended (pGlu-His-Trp-Ser-His-Gly-Trp-Phe-Pro-Gly -Lys), 250ug
250ug In stock
Regular Price:$150.00
Specifications

Product Type: Protein
Purity: This peptide was gel purified in a G-15 sephadex column, and checked by mass spectrometry.
Buffer: Phosphate Buffer Saline (PBS) pH=7.4
Comments: Synthesis was performed using Fast Moc TM chemistry on a model 431A, version 1.12 software, synthesizer (Applied Biosystems). The peptide was cleaved from the resin using a mixture of phenol, ethanedithiol, thioanisole, and trifluoroacetic acid. Samples were purified, reconstituted, and sent for Matrix-assisted laser desorption / ionization mass spectrum (HT laboratories, San Diego) for confirmation of peptide synthesis.
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.
References
  1. Kavanaugh SI, Nozaki M, Sower SA. Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey. Endocrinology. 2008 Aug;149(8):3860-9. 149(8):3860-3869
  2. Sower SA, Balz E, Aquilina-Beck A, Kavanaugh SI. Seasonal changes of brain GnRH-I, -II, and -III during the final reproductive period in adult male andfemale sea lamprey. Gen Comp Endocrinol. 2011 Jan 15;170(2):276-82.

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