An activated ester for modification of primary amine-containing molecules with DBCO moiety.


  • Biocompatible – click reaction occurs efficiently under mild conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
  • Chemoselective – azide and DBCO groups do not react or interfere with other functional groups found in biological samples, but conjugate to one another with high efficiency
  • Primary amine reactivity – modifies any amine-containing molecules with DBCO moiety
  • Short spacer – 4 carbon atom spacer arm keeps DBCO moiety close to tagged molecules

DBCO-NHS Ester reacts with primary amines (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form covalent bonds. Short spacer arm adds minimal mass to modified molecules (228.3 daltons).

This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
DBCO-C6-NHS Ester, 100 mg
100mg In stock
Regular Price:$293.00
On Sale:
DBCO-C6-NHS Ester, 1000 mg
1000mg In stock
Regular Price:$1,407.00
On Sale:

Product Type: Small Molecule
Name: DBCO-C6-NHS Ester
Chemical Formula: C23H18N2O5
Molecular Weight: 402.4
Variant MPN: A102
Format: White solid
Solubility: DMSO, DMF, DCM, THF, Chloroform
Storage: -20C. Desiccate
Shipped: Ambient


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