Anti-Caspase 11 [17D9] Antibody
This IgG2a rat monoclonal antibody was generated against the bacterial fusion protein p30 and recognizes mouse caspase 11.
Caspase 11 is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases is critical for cell apoptosis. Caspase 11 can directly activate caspase 3 under certain pathological conditions. Caspase 11 is also known to be an important activator of caspase 1.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
This IgG2a rat monoclonal antibody was generated against the bacterial fusion protein p30 and recognizes mouse caspase 11.
Caspase 11 is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases is critical for cell apoptosis. Caspase 11 can directly activate caspase 3 under certain pathological conditions. Caspase 11 is also known to be an important activator of caspase 1.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
Specifications
| Product Type: | Antibody |
| Name: | Anti-Caspase 11 (17D9) |
| Host: | Rat |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 17D9 |
| Specificity: | Caspase 11 (mouse) |
| Immunogen: | Bacterial fusion protein (p30) |
| Format: | Liquid |
| Purification Method: | Protein G affinity purified |
| Tested Applications: | WB, ELISA, IHC |
| Amount: | 100ug |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
Provider
From a laboratory at Harvard University.
References
- Juying Li et al. Flightless-1 regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. JCB, Vol. 181, No. 2, April 21, 2008
- Juying Li. Et al. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology, Vol 9, Number3, March 2007
- SJ Kang. Et al. Distinct downstream pathways of Caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death and Differentiation(2002) 9, 1115-1125
- SJ Kang. et al. Dual Role of Casepase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions. The Journal of Cell Biology, Vol. 149, Number 3, May1, 2000
- Suyue Wang. Et al. Murine Caspase-11, an Ice-Interacting Protease, Is Essential for the Activation of ICE. Cell, Vol. 92, 501-509, Feb 20, 1998
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