Anti-Caspase 11 [17D9] Antibody

This IgG2a rat monoclonal antibody was generated against the bacterial fusion protein p30 and recognizes mouse caspase 11.

Caspase 11 is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases is critical for cell apoptosis. Caspase 11 can directly activate caspase 3 under certain pathological conditions. Caspase 11 is also known to be an important activator of caspase 1.

From a laboratory at Harvard University.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EF0003
Anti-Caspase 11 [17D9] Antibody
100ug Currently Unavailable
Regular Price:$254.00
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Specifications

Product Type: Antibody
Name: Anti-Caspase 11 (17D9)
Host: Rat
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: 17D9
Specificity: Caspase 11 (mouse)
Immunogen: Bacterial fusion protein (p30)
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: WB, ELISA, IHC
Amount: 100ug
Storage: Store at 4C
Shipped: Cold packs

Provider
From a laboratory at Harvard University.
References
  1. Juying Li et al. Flightless-1 regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. JCB, Vol. 181, No. 2, April 21, 2008
  2. Juying Li. Et al. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology, Vol 9, Number3, March 2007
  3. SJ Kang. Et al. Distinct downstream pathways of Caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death and Differentiation(2002) 9, 1115-1125
  4. SJ Kang. et al. Dual Role of Casepase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions. The Journal of Cell Biology, Vol. 149, Number 3, May1, 2000
  5. Suyue Wang. Et al. Murine Caspase-11, an Ice-Interacting Protease, Is Essential for the Activation of ICE. Cell, Vol. 92, 501-509, Feb 20, 1998

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