Anti-VSV-M [23H12] Antibody

This monoclonal antibody reacts with VSV-M protein.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.

 

Catalog Number Product Size AVAILABILITY Price Qty
EB0011
Anti-VSV-M [23H12] Antibody, 100 ug
100ug (1mg/mL) In stock
Price: $356.00
Specifications
Product Type: Antibody
Name: anti-VSV-M (23H12)
Host: Mouse
Isotype: IgG2a kappa
Clonality: Monoclonal
Clone Name: 23H12
Specificity: VSV-Ind matrix (M) protein
Immunogen: VSV infection
Format: Liquid
Purity: Protein G purified
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: Western blot (1:1000)
Concentration: 1mg/mL
Amount: 100uL
Storage: -20C (avoid repeated freeze / thaw cycles)
Shipped: Cold packs
Provider
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
References
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  11. Salata C, Baritussio A, Munegato D, Calistri A, Ha HR, Bigler L, Fabris F, Parolin C, Palù G, Mirazimi A. Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process. Pathog Dis. 2015 Jul;73(5). View Article
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  16. de la Cruz-Herrera CF, Baz-Martínez M, Motiam AE, Vidal S, Collado M, Vidal A, Rodríguez MS, Esteban M, Rivas C. Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO. Sci Rep. 2017 Oct 25;7(1):14055. View Article
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