Microglial Cell Line (IMG)

Immortalized microglial cell line (IMG) isolated from the brains of adult mice.

Highlights:

  • Express the markers F4/80 and CD11b but not the neuronal marker NeuN or the astrocyte marker GFAP
  • Display a robust response (M1/M2 polarization) to inflammatory signals and can therefore be used to examine mechanisms of drug action and drug efficacy in regards to M1/M2 polarization
  • Can be induced to pro- or anti-inflammatory microglial phenotypes
  • Able to phagocytose foreign particles and misfolded proteins such as amyloid-beta peptide

Microglia cells share functional similarities with macrophages, and are thought to act as the primary immune cells of the central nervous system (CNS). They monitor their microenviornment and become activated upon detection of abnormal and/or offensive signals. Activated microglia have been found in inflammatory conditions such as brain/spinal cord injury, ischemic strokes, infections and neurodegenerative diseases. Recent findings indicate that microglia are also involved in learning and memory by regulating synaptic plasticity.

From the laboratory of Chih-Hao Lee, PhD, Harvard University.

Catalog Number Product Size AVAILABILITY Price Qty
EF4001
Microglial Cell Line (IMG), 1 vial
1 vial In stock
Price: $699.00
Specifications
Product Type: Cell Line
Name: Immortalized Microglial Cell (IMG)
Cell Type: Immortalized microglial cell
Organism: Mouse (8-wk-old C57BL/6J)
Accession ID: CVCL_HC49
Morphology: Ramified/Amoeboid
Biosafety Level: BSL2
Growth Conditions: DMEM with 4.5g/L glucose with glutamate, 10% FBS, 1% Penicillin/Streptomycin
Cryopreservation: Growth Medium + 10% DMSO
Source: Brain
Storage: Liquid nitrogen
Shipped: Dry ice
Provider
From the laboratory of Chih-Hao Lee, PhD, Harvard University.
References
  1. McCarthy RC, Lu DY, Alkhateeb A, Gardeck AM, Lee CH, Wessling-Resnick M. Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J Neuroinflammation. 2016 Jan 27;13(1):21. doi: 10.1186/s12974-016-0484-z. PubMed PMID: 26819091.

If you publish research with this product, please let us know so we can cite your paper.

 
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